3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
- CAS No.
- 1228779-96-1
- Chemical Name:
- 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
- Synonyms
- 124267;abt-1-199;EOS-60659;THP-sulfonamide;Venclexta Impurity 2;ABT-199 intermedate3;Venetoclax Intermediate;Venetoclax Intermediate 4;3-nitro-4-(oxan-4-ylmethylamino)benzenesulfonamide;3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide
- CBNumber:
- CB02735683
- Molecular Formula:
- C12H17N3O5S
- Molecular Weight:
- 315.35
- MDL Number:
- MFCD28142285
- MOL File:
- 1228779-96-1.mol
- MSDS File:
- SDS
Melting point | 188 - 191°C |
---|---|
Boiling point | 542.0±60.0 °C(Predicted) |
Density | 1.412±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 9.58±0.60(Predicted) |
form | Solid |
color | Yellow to Dark Yellow |
CAS DataBase Reference | 1228779-96-1 |
FDA UNII | 5I2EU37URS |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2932990090 |
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Matrix Scientific | 132849 | 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 97% | 1228779-96-1 | 5g | $62 | 2021-12-16 | Buy |
Apolloscientific | OR55052 | 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide | 1228779-96-1 | 1g | $66 | 2021-12-16 | Buy |
SynQuest Laboratories | 8H69-1-7N | 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide | 1228779-96-1 | 1g | $72 | 2021-12-16 | Buy |
AK Scientific | 0022AP | 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide | 1228779-96-1 | 1g | $77 | 2021-12-16 | Buy |
ChemScene | CS-0010860 | 3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide | 1228779-96-1 | 10g | $84 | 2021-12-16 | Buy |
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties,Uses,Production
Uses
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL).
Uses
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.
Synthesis
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows:
4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.
3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
View Lastest Price from 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-11-01 | 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide
1228779-96-1
|
US $0.00 / kg | 1kg | 99% | 200kg | Hangzhou ICH Biofarm Co., Ltd | ||
2023-01-12 | 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide
1228779-96-1
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2022-06-21 | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
1228779-96-1
|
US $0.00 / g | 10g | 98% | 10tons | Yangzhou Qinyuan Pharmatech Co.,ltd |
- 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfoNamide
1228779-96-1
- US $0.00 / kg
- 99%
- Hangzhou ICH Biofarm Co., Ltd
- 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)-benzenesulfonamide
1228779-96-1
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
1228779-96-1
- US $0.00 / g
- 98%
- Yangzhou Qinyuan Pharmatech Co.,ltd
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